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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2004 Vol.23 No.1

Establishment of Experimental Ventricular Septal Defect in Young Pigs
Author of the article:WEI Xin-chuan1, LIU Han-min2, SUI Dong-hu1, ZHOU Tong-fu2
Author's Workplace:(1. Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041; 2. Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu, Sichuan Province, 610041)
Key Words:ventricular septal defect (VSD); animal model
Abstract:
Objective To explore the method for establishing experimental animal model of ventricular septal defect (VSD) in young pigs. Method Thoracotomy was performed on 16 young pigs under general anaesthesia. 3 days after the operation, echocardiography was conducted to verify the existence of VSDs. The animals were catheterized one month later to obtain hemodynamic data. Results 11 pigs survived from the operation and 10 with successful acquisition of VSDs. Doppler echocardiography demonstrated the transseptal shunts with peak velocities ranged from 1.7~4.4m/sec (2.63±0.92). Cardiac catheterization showed the Qp/Qs was 1.682.12 (1.84±0.24), although the pulmonary pressures remained in normal limits. Conclusion Experimental VSD model in young pigs using modified Synhorst method was successfully established. The preliminary result shows that the VSD model using pigs is feasible and worth improving further in order to provide an useful animal model for the pathophysiological study of intracardiac left to right shunt in the future.
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