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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2004 Vol.23 No.1

Study on Morphology and Function of Retina of Wistar Rats and RCS Rate
Author of the article:YU Tao, YIN Zheng-qin, WANG Shi-jun
Author's Workplace:(Southwest Ophthalmology Hospital, Third Military Medical University, Chongqing 400038)
Key Words:retinal degeneration; animal model; flash electronicretinogram (FERG)
Abstract:Objective To study the morphology and function of retinas of RCS (Royal College Surgeon) rats. Methods Flash electronicretinogram (FERG) was detected in 20 Wistar rats and 20 RCS rats before the rats were sacrificed. The retina sections were stained with hematoxylin eosin and the immunohistochemical technic was used. Results In RCS rats, at the age of 3 months, the outer nucler layer (ONL) was lost completely. Immunohistochemistry for rhodopsin (Rho) and glial fibrillary acidic protein (GFAP) demonstrated positive immunoreaction in the outer retina, while the ONL did not stain for synaptophysin (SYN). Amplitudes of a-wave and b-wave of FERG were significantly reduced in RCS rats than in normal Wistar rats (P<0.01). Conclusion RCS rat is the useful model to study the retinal cotransplantation because it has the similar pathological changes with human patients.
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