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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
Address:College of Life Sciences, Sichuan University, No.29, Wangjiang Road, Chengdu, Sichuan Province, 610064, China
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Your Position :Home->Past Journals Catalog->2012 Vol.31 No.3

Effect of numb and numblike on cardiovascular development of mouse embryo
Author of the article:ZHAO Ming, ZHOU Hua-shan, HU Huo-z hen*
Author's Workplace:(Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, College of Life Science , Sichuan University, Chengdu 610064, China)
Key Words:cardiovascular development; numb; numblike
Abstract:Numb is the first signaling molecule found to determine cell fate in multi-cellular organisms. In mammalian, numb has four different splice variants, with a homology molecule numblike. We utilized endothelial specific recombinase Tie2-cre to knockout numb and numblike in endothelium and endocardium, and we found that the mutant mice were smaller in size at E10.0, with pericardial effusion at E10.5; besides, the dorsa aorta became thinner, and the mutant had profound defective trabeculation, but cannot pass beyond E11.0. These results suggest that numb and numblike play an important role in cardiovascular development, and it will help us to search the molecular mechanism of cardiovascular development, as well as understand the genesis of angiocardiopathy.
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