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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2012 Vol.31 No.3

Effects of ELV on the Expression of VEGF and VEGFR2 Proteins in the Testis of Adolescent Rats
Author of the article:MA Li1, MIAO Nai-zhou2, AI Qing-yan2*
Author's Workplace:(1. Room of Electron Microscopy, Medical School of Yan’an University; 2. Department of Human Histology and Embryology, Medical School of Yan’an University, Yan’an, Shaanxi 716000,China)
Key Words:VEGF; VEGFR2; experimental left varicocele (ELV); infertility; testis; immunohistochemistry
Abstract:Objective  To study the expression and location of VEGF and VEGFR2 in the testis of experimental left varicocele rats and explore the relative function of VEGF and VEGFR2. Methods   Experimental left varicocele models of SD rats were obtained by partial ligation of the left renal vein, The testis were collected at 2- and 4-week after the operation.The VEGF and VEGFR2 expression changes were observed by immunohistochemistry.Results  Immunohistochemistry results showed notable increasing of VEGF protein expression in ELV 2-week and 4-week groups compared with that of corresponding control groups; VEGF expression of testis in ELV groups occurred no changed;The results showed notable increasing of VEGFR2 protein expression in ELV 2-week groups compared with that of corresponding control groups,while VEGFR2 protein expression in ELV 4-week groups testis occurred remarkable increased compared with control groups and ELV 2-week groups. Conclusion   Experimental left varicocele affect the expression of VEGF and VEGFR2, which indicates that they may play an important role in male infertility.
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