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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->2005 Vol.24 No.1

Determination of Pharmacological Parameters for Rosiglitazone in Dogs by HPLC
Author of the article:ZHANG Yun-mei1, PAN Yong-quan2, YANG Jun-qing3, SHANG Jian-chuan4, ZHOU Qi-xin3
Author's Workplace:(1.College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400050; 2. Experimental Animal Center, Chongqing Medical University; 3. Department of Pharmacology, Chongqing Medical University; 4. Department of Chemistry, Chongqing Medical University)
Key Words:rosiglitazone maleate; HPLC; pharmacokinetics; dog
Abstract:Objective To determine the pharmacological parameters of rosiglitazone in dogs. Methods The concentration of rosiglitazone in dog plasma was determined by HPLC and the pharmacological parameters were calculated by Practical Pharmacokinetic Program Version 97 (3P97) soft. Results and Conclusions The results showed that the pharmacological characteristics of rosiglitazone in dog were one order absorption and two apartments distribution. V (c) was about 0.4231 mg/kg/ (µg·ml-1), T1/2keabout 107.6 min, CL about 0.0027 mg·kg-1·min/ (µg·ml-1).
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