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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->2010 Vol.29 No.6

Study on Joint Toxicity of 4-Nonylphenol and Benzo[a]pyrene in Odontobutis potamophila (Günther)
Author of the article:ZHAO Li, WU Ying, ZHOU Zhong-liang*, JIA Lin-zhi
Author's Workplace:(School of Life Science, East China Normal University, Shanghai 200062, China)
Key Words: Odontobutis potamophila; benzo[a]pyrene; 4-nonlyphenol, joint toxicity
Abstract:This article is aimed to study the joint toxicity of the environmental disrupt chemicals (EDC) in fish. The combined effect of BaP and NP on estradiol (E2), vitellogenin (Vtg), 7-ethoxyre sorufin O-deethylase (EROD), glutamic oxalacetic transaminase (GOT) and SOD was measured. The result showed that with an increase in the concentration of BaP, the content of E2 in serum was reduced and the activity of EROD in the liver was enhanced in female Odontobutis potamophila exposed to BaP. The activity of EROD in the liver in fish exposed to 25mg/kg BaP was higher than the control remarkably, while there were no observed differences in the activity of GOT and hepatic SOD between fish exposed to BaP and the controls. The results of the mixture test showed that the level of Vtg in male Odontobutis potamophila in test groups were 50% lower than in the control, but the level of E2 in the serum of male test fish was higher than that in the control. In the test fish exposed to 200 mg/kg NP+25 mg/kg BaP, the activity of the hepatic SOD were higher than in the control observably, while the level of serum GOT was lower than in the control. In conclusion, when exposed to the mixture of NP and BaP, the induced effect of NP on vitellogenin in male fish will be depressed by BaP. The hepatic cell will be damaged in Odontobutis potamophila by joint toxicity of NP and BaP.
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