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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2010 Vol.29 No.6

Establishment of an Experimental Autoimmune Encephalomyelitis Model in KM Mice
Author of the article:YANG Ming-li1, LUO Su-yuan1, HU Huo-zhen2, GUO Ping1
Author's Workplace:(1. Department of Cell Biology and Genetics, Zunyi Medical College, Zunyi, Guizhou Province 563003, China; 2. Department of Cell Biology, College of Life Sciences, Sichuan University, Chengdu 610041, China)
Key Words: experimental autoimmune encephalomyelitis; KM mice; multiple sclerosis; animal model
Abstract:Chinese Kun Ming (KM) mice were immunized with both guinea pig spinal cord homogenate (GPSCH) in complete Freund’s adjuvant (CFA) and pertussis toxin (PTx) to establish an experimental autoimmune encephalomyelitis (EAE) model. EAE clinical symptoms gradually worsened with the development of this disease. Perivascular cuffs of inflammatory cell infiltration, formation of glial nodules and necrosis of neurons were observed in brain slices of EAE mice, which were stained with H.E. By contrast, there were no signs of neural function disorder and parenchymal pathology in mice from the adjuvant group. This EAE model provided in this paper will be helpful to illuminate the pathogenesis of multiple sclerosis (MS).
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