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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2018 Vol.37 No.1

Nucleus Accumbens Microinjection Jak/Stat3 Inhibitor Regulate Energy Metabolism of Lasiopodomys brandtii
Author of the article:YAN Lixin1, ZHANG Zhibin2, SONG Mingjing1*
Author's Workplace:1. Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China;
2. Institute of Zoology, Chinese Academy of Science, Beijing 100101, China
Key Words:nucleus accumbens; leptin; Lasiopodomys brandtii; energy metabolism; body mass
Abstract:Objective To explore the effect of impaired leptin-Stat3 in nucleus accumbens on the metabolism and body mass of Lasiopodomys brandtii. Methods Inhibitor of Jak/Stat3 (WP1066) was injected into the nucleus accumbens of L. brandtii, and then the basic metabolism was tested by TSE metabolic cage system followed by monitoring the body mass.Results Jak/Stat3 could significantly decrease the levels of P-Stat3 and leptin in nucleus accumbens (P<0.05). However, there was no significant difference in the levels of serum leptin and blood glucose (P>0.05). The result of TSE metabolic cage system showed that the energy expenditure, cumulative O2 consumption and cumulative locomotor activity decreased significantly, while the respiratory exchange rate and cumulative drink increased significantly in experimental group (P<0.05). Moreover, the average body mass of experimental group increased significantly (P<0.05). Conclusion Inhibition of leptin-Stat3 pathway in nucleus accumbens of L. brandtii can influence energy metabolism and body mass of L. brandtii in 10 days.
2018,37(1): 57-61 收稿日期:2017-08-24
DOI:10.11984/j.issn.1000-7083.20170258
分类号:Q95-33;Q955
基金项目:国家自然科学基金项目(31471790);农业虫害鼠害综合治理研究国家重点实验室开放研究基金项目(Chinese IPM1615)
作者简介:闫立新,女,硕士研究生,主要从事行为神经学研究,E-mail:lixinyan1992@163.com
*通讯作者:宋铭晶,E-mail:songmj@cnilas.org
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