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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->2016 Vol.35 No.2

Study of the Effect of the Chuanxiong Dingtong Grains on the Rats with Migraine
Author of the article:PAN Yuan, PENG Cheng*, LIU Jianlin
Author's Workplace:Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
Key Words:Chuanxiong Dingtong grains; migraine; monoamine neurotransmitters
Abstract:Objective To investigate the effect of Chuanxiong Dingtong grains (CXDT grains) on the rats with migraine. Method A total of 60 rats were randomly divided into 6 groups including the normal control group, the model control group, the zolmitriptan control group (0.83 mg·kg-1), the high-dose (1.75 g powdered extract per kg), the medium-dose (0.88 g powdered extract per kg) and the low-dose group (0.44 g powdered extract per kg). Five days after intragastric administration of appropriate drugs, except the normal control group, the rats were subcutaneously injected with nitroglycerin (10 mg·kg-1) to establish migraine rat model. The content of 5-hydroxytryptamine (5-HT), norepinephrine (NE), endothelin (ET) in the plasma and 5-HT, NE, dopamine (DA) in the brain were tested by ELASA. Results Compared with the normal control group, the contents of 5-HT, NE, and ET were significantly decreased (P<0.05) in the plasma of the migraine model rats, and the content of 5-HT in brain tissue showed a decreasing trend, the content of NE was significantly increased (P<0.05), and the content of DA was significantly decreased (P<0.05). Therefore, CXDT grains can significantly improve the active substance in rat plasma and brain neurotransmitter content of migraine rat model. Conclusion CXDT grains had a positive effect on the rats with migraine by adjusting the levels of the brain neurotransmitters.
2016,(35): 252-255 收稿日期:2015-11-18
DOI:10.11984/j.issn.1000-7083.20150364
分类号:Q95-33
基金项目:国家支撑计划项目(2009BAI84B00)
作者简介:潘媛(1987-), 女, 博士研究生, 助理实验师, 研究方向:中药药效与毒理学, E-mail:panyuan1129@163.com
*通讯作者:彭成, E-mail:pengchengchengdu@126.com
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