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Issue:ISSN 1000-7083
          CN 51-1193/Q
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Your Position :Home->Past Journals Catalog->2016 Vol.35 No.1

Effects of Chronic Morphine Exposure and Withdrawal on Social Novelty- and Food-seeking Behaviors
Author of the article:Guzalnur Mammat, WANG Jianli*, ZHAN Bo, LIU Chaobao, CHEN Moxuan
Author's Workplace:College of Biological Sciences and Engineering, Beifang University of Nationalities, Yinchuan 750021, China
Key Words:morphine; abstinence; natural reward; social stimuli; food
Abstract:Opioid peptides play a crucial role in the control of social and non-social natural rewards. The motivation to seeking natural rewards is associated with the emotional state of an animal. The exposure and withdrawal from morphine provokes different emotional states. The present study assessed whether morphine exposure and withdrawal affects the seeking behaviors of two types of natural rewards: social novelty and food. Male mice were administered morphine (10 mg·kg-1 twice daily, or saline in control) for 14 days. 20 minutes after the last injection, locomotor activity and the approach to familiar and unfamiliar conspecifics or food were examined. Subsequently, the social novelty-seeking and food-seeking behaviors of mice that had undergone a seven-day morphine or saline withdrawal were examined. During the phases of saline exposure and withdrawal, we observed that mice would prefer food and spend more time on approaching the unfamiliar conspecifics rather than on the familiar conspecifics. Morphine exposure increased the locomotion and the morphine-exposed mice spent a similar amount of time on approaching the unfamiliar and familiar conspecifics. Morphine exposure did not significantly affect the food-seeking behavior. Compare to saline controls, morphine withdrawal lowered the time spent on approaching to food, while there were no specific effects in social novelty-seeking. These findings indicated that morphine experience significantly impaired the appetitive motivations to social stimuli and food; the incentives for the two stimuli were affected differently by chronic exposure and withdrawal from morphine, and these behavioral changes may be associated with morphine experience-induced different neuroadaptations.
2016,(1): 44-51 收稿日期:2015-07-21
DOI:10.11984/j.issn.1000-7083.20150237
分类号:Q959.837
基金项目:国家自然科学基金项目(31260513, 31460565); 北方民族大学研究生创新基金项目(YCX1526); 国家大学生创新实验项目(201411407039)
作者简介:古再丽努尔·买买提(1990-), 女, 硕士研究生
*通讯作者:王建礼, 男, 博士, 副教授, 主要从事行为生理学研究, E-mail:wang_jianli@163.com
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