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Your Position :Home->Past Journals Catalog->2016 Vol.35 No.1

Effects of Chronic Morphine Exposure and Withdrawal on Social Novelty- and Food-seeking Behaviors
Author of the article:Guzalnur Mammat, WANG Jianli*, ZHAN Bo, LIU Chaobao, CHEN Moxuan
Author's Workplace:College of Biological Sciences and Engineering, Beifang University of Nationalities, Yinchuan 750021, China
Key Words:morphine; abstinence; natural reward; social stimuli; food
Abstract:Opioid peptides play a crucial role in the control of social and non-social natural rewards. The motivation to seeking natural rewards is associated with the emotional state of an animal. The exposure and withdrawal from morphine provokes different emotional states. The present study assessed whether morphine exposure and withdrawal affects the seeking behaviors of two types of natural rewards: social novelty and food. Male mice were administered morphine (10 mg·kg-1 twice daily, or saline in control) for 14 days. 20 minutes after the last injection, locomotor activity and the approach to familiar and unfamiliar conspecifics or food were examined. Subsequently, the social novelty-seeking and food-seeking behaviors of mice that had undergone a seven-day morphine or saline withdrawal were examined. During the phases of saline exposure and withdrawal, we observed that mice would prefer food and spend more time on approaching the unfamiliar conspecifics rather than on the familiar conspecifics. Morphine exposure increased the locomotion and the morphine-exposed mice spent a similar amount of time on approaching the unfamiliar and familiar conspecifics. Morphine exposure did not significantly affect the food-seeking behavior. Compare to saline controls, morphine withdrawal lowered the time spent on approaching to food, while there were no specific effects in social novelty-seeking. These findings indicated that morphine experience significantly impaired the appetitive motivations to social stimuli and food; the incentives for the two stimuli were affected differently by chronic exposure and withdrawal from morphine, and these behavioral changes may be associated with morphine experience-induced different neuroadaptations.
2016,(1): 44-51 收稿日期:2015-07-21
基金项目:国家自然科学基金项目(31260513, 31460565); 北方民族大学研究生创新基金项目(YCX1526); 国家大学生创新实验项目(201411407039)
作者简介:古再丽努尔·买买提(1990-), 女, 硕士研究生
*通讯作者:王建礼, 男, 博士, 副教授, 主要从事行为生理学研究,
Aragona BJ, Detwiler JM, Wang ZX. 2007. Amphetamine reward in the monogamous prairie vole[J]. Neuroscience Letter, 418(2): 190-194.
Bai Y, Li Y, Lv Y, et al. 2014. Complex motivated behaviors for natural rewards following a binge-like regimen of morphine administration: mixed phenotypes of anhedonia and craving after short-term withdrawal[J]. Fronters in Behavavioral Neuroscience, 8: 23.
Banks ML, Negus SS. 2010. Effects of extended cocaine access and cocaine withdrawal on choice between cocaine and food in rhesus monkeys[J]. Neuropsychopharmacology, 35(2): 493-504.
Barnea-Ygael N, Gal R, Zangen A. 2014. Chronic cocaine administration induces long-term impairment in the drive to obtain natural reinforcers in high- but not low-demanding tasks[J]. Addiction Biology, doi: 10.1111/adb.12196.
Barr AM, Phillips AG. 1999. Withdrawal following repeated exposure to damphetamine decreases responding for a sucrose solution as measured by a progressive ratio schedule of reinforcement[J]. Psychopharmacology, 141(1): 99-106.
Bechara A, Nader K, van der Kooy D. 1998. A two-separate-motivational-systems hypothesis of opioid addiction[J]. Pharmacology Biochemistry and Behavior, 59(1): 1-17.
Broseta I, Rodriguez-Arias M, Aguilar MA, et al. 2005. Isolation decreases physical and motivational aspects of morphine withdrawal[J]. Behavioural Pharmacology, 16(3): 131-138.
Calcagnetti DJ, Schechter MD. 1992. Place conditioning reveals the rewarding aspect of social-interaction in juvenile rats[J]. Physiology & Behavior, 51(4): 667-672.
Carey RJ, Depalma G, Damianopoulos E. 2005. Evidence for Pavlovian conditioning of cocaine-induced responses linked to emotional behavioral effects[J]. Pharmacology Biochemistry & Behavior, 80(1): 123-134.
Castilho VM, Borelli KG, Brando ML, et al. 2008. Anxiety-like symptoms induced by morphine withdrawal may be due to the sensitization of the dorsal periaqueductal grey[J]. Physiology & Behavior, 94(4): 552-562.
Cooper SJ, Kirkham TC. 1993. Opioid mechanisms in the control of food consumption and taste preferences[M]// Her A. Handbook of experimental pharmacology. Berlin: Springer-Verlag, 104(II): 239-262.
Crowder WF, Hutto CW. 1992. Operant place conditioning measures examined using 2 non-drug reinforcers[J]. Pharmacology Biochemistry and Behavior, 41(4): 817-824.
Duarte RB, Patrono E, Borges AC, et al. 2014. Consumption of a highly palatable food induces a lasting place-conditioning memory in marmoset monkeys[J]. Behavioural Processes, 107: 163-166.
Dym CT, Pinhas A, Ginzberg M, et al. 2007. Genetic variance contributes to naltrexone-induced inhibition of sucrose intake in inbred and outbred mouse strains[J]. Brain Research, 1135(1): 136-145.
Fiore L, Ratti G. 2007. Remote laboratory and animal behaviour: an interactive open field system[J]. Computers & Education, 49(4): 1299-1307.
Galaj E, Cruz I, Schachar J, et al. 2013. Differential effects on natural reward processing in rats after repeated heroin[J]. Psychopharmacology (Berl), 229(1): 125-132.
Goeldner C, Lutz PE, Darcq E, et al. 2011. Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine[J]. Biological Psychiatry, 69(3): 236-244.
Kelley AE. 2004. Memory and addiction: shared neural circuitry and molecular mechanisms[J]. Neuron, 44(1): 161-179.
Kraus MA, Piper JM, Kornetsky C. 1997. Persistent increases in basal cerebral metabolic activity induced by morphine sensitization[J]. Pharmacology Biochemistry and Behavior, 57(1-2): 89-100.
Kummer K, Klement S, Eggart V, et al. 2011. Conditioned place preference for social interaction in rats: contribution of sensory components[J]. Fronters in Behavavioral Neuroscience, 5: 80.
Lutz PE, Reiss D, Ouagazzal AM, et al. 2013. A history of chronic morphine exposure during adolescence increases despair-like behaviour and strain-dependently promotes sociability in abstinent adult mice[J]. Behavioural Brain Research, 243: 44-52.
Miladi-Gorji H, Rashidy-Pour A, Fathollahi Y. 2012. Anxiety profile in morphine-dependent and withdrawn rats: effect of voluntary exercise[J]. Physiology & Behavior, 105(2): 195-202.
Moles A, Cooper SJ. 1995. Opioid modulation of sucrose intake in CD-1 mice: effects of gender and housing conditions[J]. Physiology & Behavior, 58(4): 791-796.
Moles A, Valsecchi P, Cooper SJ. 1999. Opioid modulation of socially transmitted and spontaneous food preferences in female mice[J]. Behavioural Processes, 44(3): 277-285.
Monclaro AV, Sampaio AC, Ribeiro NB, et al. 2014. Time-of-day effect on a food-induced conditioned place preference task in monkeys[J]. Behavioural Brain Research, 259: 336-341.
Motevasseli T, Rezayof A, Zarrindast MR, et al. 2010. Role of ventral hippocampal NMDA receptors in anxiolytic-like effect of morphine[J]. Physiology & Behavior, 101(5): 608-613.
Mumford L, Kumar R. 1979. Sexual behaviour of morphine-dependent and abstinent male rats[J]. Psychopharmacology, 65(2): 179-185.
Nadler JJ, Moy SS, Dold G, et al. 2004. Automated apparatus for rapid quantitation of social approach behaviors in mice[J]. Genes Brain and Behavior, 3(5): 303-314.
Niu H, Zheng Y, Huma T, et al. 2013. Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice[J]. Pharmacology Biochemistry & Behavior, 103(3): 526-534.
Nocjar C, Panksepp J. 2002. Chronic intermittent amphetamine pretreatment enhances future appetitive behavior for drug- and natural-reward: interaction with environmental variables[J]. Behavioural Brain Research, 128(2): 189-203.
Nocjar C, Panksepp J. 2007. Prior morphine experience induces long-term increases in social interest and in appetitive behavior for natural reward[J]. Behavioural Brain Research, 181(2): 191-199.
Panksepp J, Herman BH, Villberg T, et al. 1980. Endogenous opioids and social behavior[J]. Neuroscience and Biobehavioral Reviews, 4(4): 473-487.
Panksepp J, Nelson E, Bekkedal M. 1997. Brain systems for the mediation of social separation-distress and social-reward. Evolutionary antecedents and neuropeptide intermediaries[J]. Annals of the New York Academy of Sciences, 807: 78-100.
Peartree NA, Hood LE, Thiel KJ, et al. 2012. Limited physical contact through a mesh barrier is sufficient for social reward-conditioned place preference in adolescent male rats[J]. Physiology & Behavior, 105(3): 749-756.
Qi RL, Qu JG, Chen YM, et al. 2011. Differences in morphine-induced and food-induced conditioned place preference between adolescent and adult mice[J]. Zoological Research, 32(5): 528-532.
Rezayof A, Assadpour S, Alijanpour S. 2013. Morphine-induced anxiolytic-like effect in morphine-sensitized mice: involvement of ventral hippocampal nicotinic acetylcholine receptors[J]. Pharmacology Biochemistry and Behavior, 103(3): 460-466.
Shin IC, Kim HC, Swanson J, et al. 2003. Anxiolytic effects of acute morphine can be modulated by nitric oxide systems[J]. Pharmacology, 68(4): 183-189.
Thiel KJ, Okun AC, Neisewander JL. 2008. Social reward-conditioned place preference: a model revealing an interaction between cocaine and social context rewards in rats[J]. Drug and Alcohol Dependence, 96(3): 202-212.
To CT, Bagdy G. 1999. Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment[J]. Neuropharmacology, 38(2): 279-282.
Van den Berg CL, Kitchen I, Gerrits MAFM, et al. 1999a. Morphine treatment during juvenile isolation increases social activity and opioid peptides release in the adult rat[J]. Brain Research, 830(1): 16-23.
Van den Berg CL, Pijlman FT, Koning HA, et al. 1999b. Isolation changes the incentive value of sucrose and social behaviour in juvenile and adult rats[J]. Behavioural Brain Research, 106(1-2): 133-142.
Vanhille N, Belin-Rauscent A, Mar AC, et al. 2015. High locomotor reactivity to novelty is associated with an increased propensity to choose saccharin over cocaine: new insights into the vulnerability to addiction[J]. Neuropsychopharmacology, 40(3): 577-589.
Walter H, Abler B, Ciaramidaro A, et al. 2005. Motivating forces of human actions: neuroimaging reward and social interaction[J]. Brain Research Bulletin, 67(5): 368-381.
Zhan B, Ma HY, Wang JL, et al. 2015. Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice[J]. Zoological Research, 36(2): 103-108.
Zhang D, Zhou X, Wang X, et al. 2007. Morphine withdrawal decreases responding reinforced by sucrose self-administration in progressive ratio[J]. Addiction Biology, 12(2): 152-157.
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