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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->1996 Vol.15 No.4

Experimental Infection and Development of Periodic Brugia malayi in Mice
Author of the article:FANG Ren-li, XU Xiu-shu
Author's Workplace:(Guizhou Provincial Institute of Parasitic Diseases, Guiyang 55004)
Key Words:mouse; jirds (Meriones unguiculatus); Brugia malayi; micromaria; larvae; adult worms
Abstract:In order to explore a new kind of animal model, microfilariae of Brugia malayi were collected from jirds (Meriones unguiculatus) and infected into Aedes togoi. The infective larvae (L3) harvested from the Ae. togoi were then experimentally infected by intrapertoneal inoculation with 60 300 L3 per mouse into 55 mice (Kunming strain). After infection, peritoneal fluid was collected and the mice were dissected at various intervals. At 14, 30, 60, 140 and 160 days after infection, the 3rd or 4th stage larvae as well as juveniles and adult worms were collected from mice and measured morphologically. The infection rate or mice reached 34.6% (9/26). 91 129 days after infection, 1 6 microfilariae /60 μl were found in peritoneal fluid. The results indicated that the periodic B. malayi could develop to mature stage adult and reproduce microfilariae in Kunming strain mice. The study also showed that B. malayi could be maintained in laboratory and used for research on control of lymphatic filariasis.
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