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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2014 Vol.33 No.2

The Evolutionary Trace Analysis of Biological Clock Protein TIME-EA4 in the Silkworm Bombyx mori
Author of the article:WANG Wendong1, XU Shiqing2*
Author's Workplace:(1. Lab Medicine College, Hebei North University, Zhangjiakou, Hebei Province 075000, China; 2. Medical College of Soochow University, Suzhou, Jiangsu Province 215123, China)
Key Words:Bombyx mori; biological clock; bioinformatics; molecular evolution; evolutionary trace
Abstract:Bombyx mori is the model insect of Lepioloptera with diapause during the egg stage, and the activation of diapause eggs is closely related to the biological clock protein TIME-EA4. TIME-EA4 has stable Cu/Zn SOD activity and one-time transitory ATPase activity. Numerous studies have focused on the structural and functional characteristics of TIME-EA4. The molecular evolution of this protein has received little attention. In this study, bioinformatics methods were used to analyze the evolutionary trace of TIME-EA4. The results showed that 91.2% of the important amino acid residues in TIME-EA4 were consistent with Cu/Zn SOD. However, there were some differences such as composition, amino acid residue polarity and bonded atoms in Cu/Zn ion binding sites were observed between these proteins.
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